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Forschung Gottfried Schatz Forschungszentrum

Research focus Metabolism

PI: Gernot Grabner

Focus: We investigate how alterations in lipid metabolism affect physiological processes and disease development. We are working on lipid-degrading enzymes (lipases) particularly in inflammatory and degenerative diseases of the central nervous system. Our interdisciplinary approach includes biochemical methods, molecular biology techniques, histological-, lipid-, and behavioral analyses. We also develop chemical tools to specifically modulate the activity of lipases and advance innovative therapeutic approaches.

Network: We collaborate closely with researchers from the Medical University of Graz (Dagmar Kratky, , Gerd Leitinger, ) as well as (Uni Graz), (TU Graz), (UMC Amsterdam), (TU Wien), (MedUni Wien), and (Uni Leiden).

Projects

Targeting PNPLA3 activity to elucidate its role in MASLD

  • Liver steatosis affects approximately one in four people worldwide and can progress to severe liver disease like cirrhosis, cancer, and liver failure. A genetic variant in a gene called PNPLA3 significantly increases disease risk, yet its precise role is not fully understood. In this interdisciplinary research project, new chemical tools will be developed to investigate the function of PNPLA3 in human model systems, to identify new strategies for prevention and therapy.
  • Duration: 2026 – 2030
  • Funded by: FWF
  • Project partners: Rolf Breinbauer (TU Graz), Michael Trauner (MedUni Vienna), Mario van der Stelt (Uni Leiden), Karl Gruber (Uni Graz)

Division of Molecular Biology and Biochemistry

Gernot Grabner 
T: +43 316 385 71971
Gernot Grabner

Team

Members