BMP is a glycerophospholipid found in intraluminal vesicles of late endosomes/lysosomes and at low concentrations in the circulation. It is highly relevant for metabolic homeostasis and human disease due to its key role in the regulation of lysosomal integrity and function. However, fundamental aspects of BMP metabolism remain to be resolved. PP07 focuses on the identification and characterization of enzymes catalyzing BMP synthesis and hydrolysis to gain important new insights into BMP metabolism. PP07 will perform gain- and loss-of-function experiments with newly discovered enzymes and characterize mouse strains lacking BMP synthase/hydrolase activity. This project will provide detailed insights into the role of the identified enzymes in BMP metabolism.
